• Integrates scientific foundations with clinical relevance for clear understanding
• Highlights advances in use of blood products and discusses current clinical controversies

Table of Contents

Part I. History

• 1. A Brief History of Blood Transfusion

Part II. Blood Banking

A. Immunohematology

i. Basic Principles

• 2. Principles of the Immune System Central to Transfusion Medicine
• 3. Principles of the Complement System Central to Transfusion Medicine
• 4. Principles of Red Blood Cell Allo- and Autoantibody Formation and Function

ii. Red Blood Cell, Platelet and Leukocyte Antigens and Antibodies

• 5. Membrane Blood Group Antigens and Antibodies
• 6. ABO and Related Antigens and Antibodies
• 7. Rh, Kell, Duffy, and Kidd Antigens and Antibodies
• 8. Other Blood Group Antigens and Antibodies
• 9. Human Platelet Antigens and Antibodies
• 10. HLA and Granulocyte Antigens and Antibodies

B. Blood Donation, Manufacturing, Testing and Storage

• 11. Blood Donation and Collection
• 12. Blood Manufacturing: Component Preparation, Storage and Transportation
• 13. Red Blood Cell Metabolism During Storage: Basic Principles and Practical Aspects
• 14. Infectious Disease Testing: Basic Principles and Practical Aspects

C. Regulatory, Quality and Legal Principles

• 15. Regulatory Principles and Issues Central to Blood Banking and Transfusion Medicine
• 16. Quality Assurance, Control and Improvement and Accreditation
• 17. Legal Principles and Issues Central to Transfusion Medicine

D. Specific Blood Components

• 18. Packed Red Blood Cell and Related Products
• 19. Fresh Frozen Plasma and Related Products
• 20. Cryoprecipitate and Related Products
• 21. Albumin
• 22. IVIg and Derivatives
• 23. Platelets and Related Products
• 24.Granulocytes
• 25. Coagulation Factor Preparations

E. Special Processes and Products

• 26. Leukocyte Reduced Products
• 27. Virus Safe Products: Pathogen Reduction and Inactivation
• 28. Irradiated Products
• 29. Washed and/or Volume Reduced Blood Components
• 30. Blood Management: Conservation, Salvage and Alternatives to Allogeneic Transfusion
• 31. Blood Substitutes: Basic Principles and Pracitcal Aspects

Part III. Transfusion Medicine

A. Transfusion in Specific Clinical Settings

• 32. Red Blood Cell Transfusion: Surgical and Traumatic Blood Loss and Anemia
• 33. Post-Transfusion Red Blood Cell and Platelet Survical and Kinetics: Basic Principles and Practical Aspects
• 34. Transfusion of the Patient with Congenital Coagulation Defects
• 35. Transfusion of the Patient with Acquired Coagulation Defects
• 36. Obstetric and Intrauterine Transfusion
• 37. Transfusion of the Neonates and Pediatric Patients
• 38. Transfusion of the Hemoglobinopathy Patient
• 39. Transfusion to Bone Marrow or Solid Organ Transplant Recipients
• 40. Transfusion of the Platelet Refractory Patient
• 41. Transfusion of the Patient with an Autoimmune Hemolytic Anemia
• 42. Transfusion in Economically-Restricted Countries and Developing Countries

B. Complications of Transfusion

i. Infectious Complications

• 43. Hepatitis A, B, and Non-A, Non-B, Non-C Viruses
• 44. Hepatitis C
• 45. HIV, HTLV, and Other Retroviruses
• 46. Human Herpesvirus Infections
• 47. Bacterial Infections: Bacterial Contamination, Testing and Post Transfusion Complications
• 48. Other Viral, Bacterial and Prion-Based Infectious Complications

ii. Non-Infectious Complications

• 49. Acute and Delayed Hemolytic Transfusion Reactions
• 50. Febrile, Allergic, and Other Noninfectious Transfusion Reactions
• 51. Transfusion-Related Acute Lung Injury
• 52. Transfusion-Related Immunomodulation
• 53. Post-Transfusion Engraftment Syndromes: Microchimerism and TA-GvHD

C. Therapeutic Apheresis

• 54. Therapeutic Apheresis: Basic Principles and Practical Aspects
• 55. Therapeutic Plasma Exchange
• 56. Therapeutic Cytapheresis

D. Cellular Therapies and Tissue Banking

• 57. The Role of Transfusion Medicine in Cellular Therapies
• 58. Bone Marrow and Peripheral Blood Stem Cells: Collection, Processing and Transfusion
• 59. Umbilical Cord Blood Stem Cells: Collection, Processing and Transfusion
• 60. Mononuclear Cell-Based Preparations
• 61. Tissue Banking in the Hospital Setting